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WOW! OMG! Interesting article- Mycoplasms cause of Fibro?
6 Replies
larry - January 27

Here is a very interesting article andi posted on the fibro-md forum that is very eye-openng as it suspects that mycoplasms are the cause of fibro and it is contagious. .The article is from Newdaynews Health Matters Hopefully this can help you also! .....................................
..................................(Th
e
Fibro center checks for this and I was told I have 24X the normal level in my body.) ........................................... HOW WAS MYCOPLASMA INFECTION IDENTIFIED IN GULF WAR SYNDROME and CFIDS PATIENTS? -----------------------
The information trail started with Garth and Nancy Nicolson. Their daughter returned from the Gulf War with an unexplained illness. Soon after, her parents both became ill with the same symptoms. Medical tests revealed nothing abnormal, but they all continued to worsen. --------------------------
----------

Fortunately,
however, the Nicolson�s were molecular pathologists with an entire research laboratory at their disposal. They drew blood and tissue samples from themselves and their daughter, and set the research team, to work. -------------------------------
----------------------

Garth
Nicolson Ph.D. is a professor and former chairman of the Department of Tumor Biology at the University of Texas, M.D. Anderson Cancer Center, Houston, TX. He is also a professor of Internal Medicine, Pathology and Laboratory Medicine at the University of Texas Medical School. He has published over 500 scientific and medical papers, has edited 14 books, he is the current editor of two scientific and medical journals. Dr. Nicolson has been nominated for the Nobel Prize in cell microbiology, is among the 100 most cited researchers in the world, and sits on the board of the American Association of Cancer Research. ----------------------------------
-------------------------

Nancy
Nicolson, Ph.D. is president of the Rhodon Foundation for Biomedical Research. She, also, has published numerous scientific papers and was a professor in the Department of Immunology and Microbiology at Baylor College of Medicine. ------------------------------
-----------------------

Wha
t
they found was a living Mycoplasma pathogen. In order to find this organism, they had to break open the leukocytes (white blood cells), and perform a specific test called a Polymerase Chain Reaction (PCR) of the DNA of the organism. Nancy also perfected another test, called Gene Tracking, which confirms the PCR results. (1) ------------------------------------------

To gather more information, they then started testing other Gulf War Illness (GWI) patients. What they found was that approximately 50% were positive for the live organism. ---------------------------------
---------------------------

Th
e
Nicolson�s then researched treatment options and found a number of antibiotics that were effective against the organism. (2) After a lenghty course of antibiotics, they recovered. But, the word was out, and requests for testing of GWI patients kept coming in to the lab. They were inundated! As their evidence mounted, they published their data (3) (4) (5) and testified before the President�s Panel on Gulf War Illnesses. (6) ---------------------------
--------------------

The
n
the connection was made between GWI and CFIDS. (7) The Nicolson�s began running tests of those with CFIDS---with the same results-- approximately 50% positive! Garth and Nancy Nicolson even wrote an article for the CFIDS Chronicle outlining the diagnosis and treatment of GWI/CFIDS. (
------------------------------------
---------------------------------
Man
y
have begun treatment with the antibiotics recommended by the Nicolson�s have had tremendous success. Some of these have been ill with CFS/FMS/MCS for 15-20 years. But, they are feeling better for the first time since becoming ill! Some have even returned to work. ---------------------------------

WHAT IS MYCOPLASMA?
Mycoplasmas are the smallest and simplest organism known. They are not new. They were discovered over 100 years ago and evolved from bacteria. The "garden variety" mycoplasma is not usually associated with severe diseases. (13)
-------------------------------However, sometime over the past 30 years, the organism has been altered to become more lethal. The Mycoplasmas found by the Nicolson�s, in their lab, contain unusual gene sequences that were probably inserted into the Mycoplasma by a specific laboratory procedure. This discovery has led them to conclude that the new forms of mycoplasma were specifically engineered for germ warfare. (9) -------------------------------------------

In this way, the Mycoplasmas have became more invasive, more difficult to find, and capable of causing severe diseases in humans. Diseases, like Gulf War Illness, CFS, FMS, MCS, Rheumatoid Arthritis, and AIDS, for instance.
----------------------------------
-------------------------------
The
earlier form of Mycoplasma was studied by Dr. Shyh Lo, formerly of Tanox Biosystems, a spin-off biotechnology company from the Baylor College of Medicine, but now affiliated with the Armed Forces Institute of Pathology in Washington D.C. Dr. Lo has been credited with discovering the new pathogenic form of Mycoplasmas, and he holds several patents on methods for handling the organisms for study and development. (10) ---------------------------------
---------------------------

Dr
.
Lo lists the following diseases caused by Mycoplasma:
HIV infection, AIDS, Aids Related Complex (ARC), Chronic Fatigue Syndrome, Wegener�s Disease, Sarcoidosis, Respiratory Distress Syndrome, Kibuchi�s Disease, Alzheimer�s Disease, and Lupus. (10) In addition, Baseman and Tully have reviewed the literature on the role of Mycoplasmal infections in human disease and have concluded that they are important factors or co-factors in a variety of chronic illnesses. (11) ----------------------------------------------

Unlike bacteria, the Mycoplasma has no cell wall. This enables it to invade tissue cells, incorporating the cell's nutrients, and using the cell to replicate itself (much like a retrovirus). (13) ----------------------------------------

When the Mycoplasma breaks out of the cell, it takes a piece of the host cell membrane with it. When the immune system attacks the Mycoplasma, it also gets "turned on" to attacking the host cell. In this way, an autoimmune condition can begin. ------------------------------

Autoimmune conditions associated with Mycoplasmas include arthritis, Fibromyalgia, myositis, thyroid dysfunction (Hashimoto�s or Grave�s Diseases), and adrenal dysfunction, signs and symptoms of Lupus, Multiple Sclerosis, and Lou Gehrig�s Disease. (12) ------------------------------------------

The Mycoplasma organism has the capacity to invade cells, tissues and blood, producing systemic infections in numerous organ systems. it can penetrate the central and peripheral nervous system. Because it can damage the immune system by invading natural killer (NK) cells, it weakens them, reduces their numbers, and renders them susceptible to viral infections (14) (15) (16) This may also explain the environmentally sensitive responses that are seen with CFIDS and MCS.
-----------------------------------
-------------------------
Mycoplasma
infection can trigger inflammatory cytokine over-production commonly seen in CFS/FMS. With the induction of CD-4+ helper cells of the immune system, an over production of cytokines such as Interleukin-1, Interleukin-6 and Tumor Necrosis Factor-alpha occurs. (15)(16)(17) These elevated cytokines have been implicated in the development of many of the CFS/FMS symptoms, including neurological involvement. (19)(20)
------------------------
----------------------
Th
e
Mycoplasma is a slow-growing, stealth-type organism that can cause the patient to be very ill. It activates the immune system, then can successfully hide from it within the host immune cells. It can then circulate throughout the body and go wherever a white blood cell can go. It can cause infection deep within any or all organs. It can even cross the blood/brain barrier and cause brain and spinal infection. It has also been known to cross the placental barrier to an unborn fetus.
-------------------------------
--------------------------
Unles
s
the white blood cell is split open and examined for the evidence of the live organism, it can go undetected for years. Because the organism resides deep within the cells, conventional antibody tests may be relatively useless. (21) The splitting open (fraction) of leukocytes (white blood cells) from a fresh blood sample, with a forensic PCR test is the most accurate way to detect the presence of active infection with a live pathogen. Further gene-tracking techniques perfected by the Nicolson�s are even more accurate. (22)
---------------------------
-------------------
CONTAGIO
N

Although the researchers have not clearly established how contagious the Mycoplasmas are, they have made some inferences from the data they have collected. The Mycoplasma organism has been found in the blood and body fluids, spinal fluid, bone marrow, urine, and in the lungs, nose and mouth. The Mycoplasma is reported to be able to survive for two hours outside the body. Of those with Gulf War Illness, 50% of their spouses have contracted the disease and 100% of their children. Several babies have also been known to be born with the disease. Some sort of chemical exposure or immune distress (i.e., auto accident, surgery, cancer) appears to pre-date the onset of illness. ----------------------------
-----------------------

O
f
those with CFS, FMS, and MCS, numerous friends and spouses have the illness, as well as close relatives. So, from the anecdotal reports, it would appear that Mycoplasma is contagious after both casual and intimate contact. This means that the organism may possibly be passed to another through sputum (coughing droplets that contain the organism), saliva, sexual secretions, blood, and urine. The disease is also developing in family pets.
---------------------------
--------------------------
I
f
one tests positive for any of the Mycoplasmas, in order to safeguard those with whom you have close contact, it would be prudent to do the following: Wash your hands a lot, never share your food or drink with another, wash eating utensils with extremely hot water, keep your hands away from your face, avoid closed-air spaces where air is re-circulated (i.e., offices, airplanes), and use protective sexual practices.
------------------------------
----------------------
TREATMEN
T

If detected early, the diseases associated with invasive mycoplasmal infections are treatable with long cycles of high-dose antibiotics. (23)(24)(25) Followed with long cycles of low dose antibiotics. Since the organism is a slow-growing, intracellular type with a long life cycle, several, long term courses of antibiotics may be necessary. The infection may need to be treated for several months or years. (The disease is treated much as Lyme�s Disease is treated.) If a person is taking antibiotics, the testing will not detect the presence of Mycoplasma in the blood. And, if a person has been taking antibiotics, they must wait for at least two months, after stopping the antibiotics, for the test to be accurate.
As yet, we do not know if antibiotics are a cure for Mycoplasma infections. Mycoplasma fermentans (incognitus) has the ability to enter any cell and alter itself, changing its cellular makeup with every cell division. This may make it impossible for readily available antibiotics to clear the body of this organism. (14) Also, one antibiotic may not be appropriate for all species of Mycoplasma. --------------------------------------

What we are hoping for is to cause the organism to be diminished or go dormant until a cure is discovered. To do that, we need to kill as much of the live organisms from our bodies as possible with the antibiotics. Once our white blood cells are free of the infection, then they can become healthier and can, hopefully, do a better job to keep the Mycoplasma under control. This may take several months or years of antibiotic treatment to accomplish. During this time, it is important to not stop taking the antibiotic too early, for a relapse is certain.
---------------------------------
-----------------------
CONCLUSION

Mycoplasmic infection appears to cause most of the symptoms of CFS/FMS/MCS. It can also account for most of the dysregulation of the immune system and the abnormal immune tests.
It seems prudent to be tested for this organism, and if positive, to be treated with the recommended antibiotics.
_________________

 

dream69 - January 28

I work at MD Anderson, so I will try to get in contact with this doctor.

 

Patrice - January 28

Larry and Dream69 ... this is a very thought-provoking post. Dream69, if you could get more information on this, I'm sure all the readers would be interested. I plan to share this with my Rheumatologist, also. Thanks.

 

tcmby - January 31

oops... I meant to post this here: hi larry, you said that "Almost all fibro patients have thyroid and other gland imbalances due to trauma, physical and emotional, stress, viruses or bacteria infections as well as nutritional defiecencies"... do you think that fibro is caused when our sensitive nervous systems get a shock or trauma which starts a ripple effect of symptoms all the way to a diagosis? One specialist I saw told me that he fully believed that fibro & cfs are caused by an over-sensitive nervous system that can only handle so many stressors for so long... until the bottom just drops out & bang... fibro! thoughts?

 

JJ1 - February 1

tcmby, that is certainly how I feel my fibro started. I was bearing about all the stress I could handle taking care of terminally ill parents while trying to keep life as normal as possible for my elementary kids and work full time plus and an already stressful job. Once both parents had passed away, all heck broke loose with my body. It was like the it was like my body had held back as long as it could and finally succumbed to the stress.

 

Iinda - February 1

I totally agree with you JJ. My fibro started after a series of emotionally traumatic events, one after the other. My body just couldn't contain the stress anymore. The symptoms started spilling over. The worst was the first few years. All the crazy symptoms with no answers, wondering what the devil was wrong with me. That fear was terrible. The worst. I strongly believe there is a stress component at play here.

 

JJ1 - February 1

I remember having episodes of sore joints and continually going back to my orthopaedic doctor with them finding nothing wrong. I was sure they thought I was a hypochondriac. At the same time I would feel as though I was coming down with a horrible flu one day sore throat and all then the next day would be fine. Finally the ortho doctor said that there was nothing that they could do for me and suggested the rheumatologist and finally a diagnosis. My pains have always been more in my extremeties rather than the typical fibro tenderpoints more near the core of the body and my pain is not chronic, so I have always been sceptical of my fibro diagnosis, but right now it is all that I have.

 

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